Pakistan Kidney & Liver Institute & Research Centre (PKLI-RC) Monday-Friday 09:00 am - 05:00 pm

Category Archives: Health care

Polycystic liver disease (PLD): Symptoms & Health Impact

What is polycystic liver disease?

polycystic liver disease:

Polycystic liver disease (PLD) is a genetic disorder characterized by the growth of numerous cysts, or fluid-filled sacs, in the liver. These cysts can range in size from a few millimeters to more than 20 centimeters and can cause the liver to become enlarged and distorted.

PLD can occur in isolation, or it can be associated with other conditions such as polycystic kidney disease (PKD) or autosomal dominant polycystic kidney disease (ADPKD). In the latter case, PLD is often referred to as autosomal dominant polycystic liver disease (ADPLD).

What are the Symptoms of Polycystic Liver Disease?

Symptoms of Polycystic Liver Disease:

Many people with PLD have no symptoms, and the condition is often discovered incidentally during imaging tests performed for other reasons. However, as the cysts grow and the liver becomes enlarged, it can cause a range of symptoms, including:

Abdominal pain:

This is the most common symptom of PLD, and it can range from mild discomfort to severe, debilitating pain. The pain is often described as a dull ache in the upper right quadrant of the abdomen and may be worsened by eating or physical activity.

Abdominal swelling:

As the liver enlarges, it can cause the abdomen to swell or become distended. This may be noticeable as a bulge or protrusion in the belly.

Nausea and vomiting:

PLD can cause feelings of nausea and may lead to vomiting, especially after eating a large meal.


In rare cases, PLD can cause jaundice, a yellowing of the skin and whites of the eyes. This occurs when the cysts compress the bile ducts in the liver, leading to a buildup of bilirubin (a waste product) in the blood.

Shortness of breath:

In very severe cases, PLD can cause the liver to push against the diaphragm (the muscle that separates the chest cavity from the abdomen), making it difficult to breathe.

How does Polycystic Liver Disease affect your overall health?

PLD can have a significant impact on a person’s overall health and quality of life, particularly as the cysts grow and the liver becomes more enlarged. Here are some ways that PLD can affect your health:

Decreased liver function:

As the cysts grow and the liver becomes more distorted, it can affect the liver’s ability to function properly. This can lead to a range of complications, including jaundice, ascites (fluid buildup in the abdomen), and liver failure.

Pain and discomfort:

As mentioned above, abdominal pain is a common symptom of PLD and can be quite severe. This can lead to decreased quality of life and limitations in daily activities.

Digestive problems:

PLD can cause digestive problems such as nausea, vomiting, and difficulty digesting food. This can lead to weight loss and malnutrition if left untreated.

Respiratory problems:

In severe cases, PLD can cause compression of the diaphragm, leading to difficulty breathing and respiratory distress.

Psychological impact:

Living with a chronic illness like PLD can be stressful and can take a toll on a person’s mental health. Many people with PLD report feelings of anxiety, depression, and isolation.

What is Treatment for Polycystic Liver Disease?

Treatment for Polycystic Liver Disease:

There is no cure for PLD, but treatment options are available to help manage symptoms and slow the growth of the cysts. Here are some of the treatment options that may be recommended:

Pain management:

Over-the-counter pain relievers like acetaminophen or ibuprofen may be recommended to help manage abdominal pain.

Polycystic liver disease (PLD) is a genetic disorder characterized by the growth of multiple cysts, or fluid-filled sacs, in the liver. These cysts can vary in size from a few millimeters to more than 20 centimeters and can cause the liver to become enlarged and distorted. PLD can occur alone, or it can be associated with other conditions such as polycystic kidney disease (PKD) or autosomal dominant polycystic kidney disease (ADPKD).

PLD affects both men and women equally, and it is estimated to affect between 1 in 1000 and 1 in 10000 people worldwide. It is usually diagnosed in adulthood, but it can occur at any age.

Causes of Polycystic Liver Disease:

PLD is a genetic disorder caused by mutations in one of several genes involved in regulating cell growth and division. The specific genes involved vary depending on the type of PLD. For example, mutations in the PRKCSH and SEC63 genes have been associated with autosomal dominant polycystic liver disease (ADPLD), while mutations in the PKD1 and PKD2 genes are associated

with polycystic kidney disease (PKD) and ADPKD.

The mutations in these genes cause an abnormal proliferation of cells in the liver, leading to the formation of cysts. The cysts grow over time and can eventually cause the liver to become enlarged and distorted.




Treatment Options:

Treatment options for PLD depend on the severity of the disease and the symptoms that a person is experiencing. In some cases, no treatment is necessary, and the disease can be managed through regular monitoring and lifestyle changes. However, in more severe cases, treatment may be necessary to manage symptoms, prevent complications, and improve quality of life


Here are some of the treatment options that may be recommended:

Lifestyle changes:

Making certain lifestyle changes can help manage PLD symptoms and prevent complications. For example, avoiding alcohol and caffeine, eating a healthy diet, and getting regular exercise can all be beneficial.

Pain management:

Pain is a common symptom of PLD, and pain management strategies may be recommended to help alleviate discomfort. Over-the-counter pain medications like acetaminophen or ibuprofen can help manage mild to moderate pain, while prescription pain medication may be necessary for more severe pain.

Drainage procedures: In some cases, cysts may need to be drained to alleviate pain or prevent complications. This can be done through a procedure called percutaneous aspiration or sclerotherapy, in which a needle is inserted into the cyst and the fluid is drained. This can be done under ultrasound guidance to ensure the needle is properly placed.


Surgery may be necessary to remove large cysts or to alleviate symptoms that are not responding to other treatments. There are several surgical options for PLD, including laparoscopic cyst fenestration, which involves creating a small opening in the cyst to drain it, or liver resection, which involves removing a portion of the liver containing cysts.

Liver transplant:

In very severe cases of PLD, liver transplant may be necessary to replace the damaged liver with a healthy liver from a donor. This is typically reserved for cases in which the liver is failing and other treatments have been unsuccessful.

It’s important to note that PLD is a chronic condition, and there is currently no cure. Treatment is aimed at managing symptoms and preventing complications. Regular monitoring is important to ensure that the disease is not progressing and that any complications are caught early and treated appropriately.

In addition to these treatment options, there are several ongoing research studies aimed at developing new treatments for PLD. These include studies of new drugs that may help slow the growth of cysts, as well as studies of gene therapy and other novel approaches to treating the disease.

polycystic liver disease is a genetic disorder characterized by the growth of multiple cysts in the liver. While many people with PLD have no symptoms, the disease can cause abdominal pain, swelling, nausea, and other digestive problems as the cysts grow and the liver becomes enlarged.

While there is currently no cure for PLD, ongoing research is aimed at developing new treatments to help manage the disease and improve the quality of life for those living with it.

Health Benefits of Persimmon



The Japanese fruit is called different names such as Amlok Japanese

fruit and Persimmon in English. Persimmon looks very beautiful and

pleasant to look at. Its shape is similar to a tomato but the only difference

is that this tomato is red and the Japanese fruit is orange in color.

Persimmon is very easy to eat, its taste is sweet and the pulp is extremely soft.

It is famous all over Pakistan for its qualities.

Some people get old before their age due to the wrong diet or due to many diseases in the body.

This fruit contains vitamins and antioxidants that enhance our

health as well as our beauty and prevents premature aging.

Good health ensures a sound mind and a healthy body.

This fruit is rich in nutrients like protein, calcium, phosphorus, potassium, etc. Japanese fruit peel is also rich in natural nutrients.

According to the Pakistani climate, cultivation of this fruit is better here and it is cultivated on a large scale. Therefore, the cultivation of this fruit is increasing day by day. This fruit is from some villages in Pakistan, first, it was cultivated in China, then it was cultivated in Japan, and in Pakistan, it was exported from Japan, which is why this fruit is called Japanese fruit.

This fruit is a winter fruit.

Japanese fruit is also cultivated in the Kashmir and Swat regions of Pakistan.

The effect of Japanese fruit is hot in the mood, so this fruit should be eaten in moderation. Always eat this fruit ripe as raw fruit can be harmful. The fruit is abundant in Kashmir. These fruits are also useful in making various dishes and puddings

Amazing Health Benefits of persimmon

Persimmons are rich in vitamins, minerals, and antioxidants, which each provide important health benefits. For example, vitamin C helps support the immune system and protect against heart disease.

Eating this fruit reduces back pain. Complaints of back pain are seen more in women, so they should eat Japanese fruit like other fruits to get rid of back pain easily.

Especially when a woman gives birth to a child, her back often has pain because of the

injections in the back and the pain in the lower back is immense, due to which women cannot perform their daily tasks well. get Whether the pain is minor or major, these pains can be avoided with medical treatment as well as home remedies.

     1. For Sore Throat

It is beneficial in sore throat and sore throat. Often due to colds, our throat becomes dry and a dry cough occurs which is also quite painful. In case of a cold, feed Japanese fruit to children and adults, it can be used to get rid of

sore throat.

  1. Useful in Appendicitis

Appendicitis patients should eat this fruit; it will reduce the disease. Many people who are suffering from a severe painful disease like appendicitis have to eat many things because the intensity of the pain is unbearable. Is.

Therefore, take care of your diet as much as possible and make it mandatory to use this fruit in your diet. It not only helps to fight one disease but also protects against many diseases in the body.

  1. Removes Physical Weakness

It is very useful for all people who are busy with work all day. In today’s busy time, every person is busy with work so everyone is tired after work and not able to prepare themselves for the next work but this fruit contains minerals that make our body strong. and provide agility for everyday work.

It increases our immunity. Leads to the removal of weakness. Removes weakness in the body, and strengthens the body to fight against many dangerous diseases.

This fruit is also considered special for male potency and they eat it with

great enthusiasm.

The Japanese fruit i.e., Amulek is rich in sugars and fructose which energizes the body and also reduces the effects of stress and lethargy. Very useful for children and adults participating in sports.

  1. Improves Eyesight

The compounds found in this fruit give strength to our eyes, especially this fruit is very useful for people who have already damaged eyes but they want our eyes not to deteriorate further. The usefulness of this fruit is a natural gift.

  1. Use in Blood Pressure Disease

Japanese fruit is rich in potassium which is useful for patients with high blood pressure. Its use keeps high blood pressure under control. The use of this fruit in fruits does a complete job of delivering blood to every part of the body. It has been proved by research that using Japanese fruit can easily get rid of diseases like high blood pressure.

  1. Proven to be Beneficial in Cancer

Being an excellent source of antioxidants to prevent cancer, this fruit scavenges free radicals that destroy our healthy cells and cause major diseases like


They damage the cells first and then eventually lead to cancer. But the

vitamin A and botulinic acid in the Japanese fruit increase its ability to

fight cancer.

  1. For Muscles and joints of the body

Muscle stiffness from strenuous physical activity and



1)Persimmons are also high in soluble dietary fiber, which

slows the digestion of carbohydrates, preventing spikes in blood sugar.


2) Eating this fruit reduces back pain. Complaints of back pain are seen more in women, so they should eat Japanese fruit like other fruits to get rid of back pain easily.

3) The effect of Japanese fruit is hot in the mood, so this fruit should be eaten in moderation. Always eat this fruit ripe as raw fruit can be harmful







Boiled Egg Benefits

The Surprising Benefits of Boiled Eggs

“The Surprising Benefits of Boiled Eggs: Why You Should Add Them to Your Diet”


It would not be wrong to call a healthy breakfast the main meal of the day, skipping breakfast not only causes weight gain but also affects your memory. For a healthy breakfast, an early morning boiled egg can be the best choice.

Eggs are rich in protein, iron, amino acids, and antioxidants. By eating two eggs daily, the body gets 12 grams of protein, while vitamins A, D, B, iodine, and other ingredients are also available.

  Surprising benefits of eggs

Eggs are among the foods that are popular around the world and are considered complete foods.

Eggs are considered a complete food because the basic ingredients present in them are very beneficial for health.

 A boiled egg contains the following ingredients:
  • Phosphorus
  • Vitamin A
  • Selenium
  • Folate
  • Vitamin B2
  • Vitamin B5
  • Vitamin B1


Along with this, eggs also contain good amounts of vitamin D, vitamin E, vitamin K, vitamin B6, calcium, and zinc. Eggs can be consumed at any time of the day or night, but most people consume them as breakfast because consuming eggs in the morning provides the body with the required amount of nutrients that are healthy. are considered necessary for life. Apart from this, many other medical benefits can be obtained from eggs.

Medicinal benefits of eggs

The following medical benefits can be obtained from eggs!

Balanced Cholesterol

One egg contains one hundred and sixty-two milligrams of cholesterol. There are two types of cholesterol, good and bad. The good type of cholesterol has beneficial effects on health while the bad type has harmful effects on health. Eggs contain good cholesterol, which is not associated with heart disease. Regular consumption of eggs increases the good type of cholesterol.

Weight loss

One egg contains 78 calories and contains no carbohydrates at all. So, after eating it you do not feel hungry and your stomach remains full. Eating a boiled egg for breakfast keeps you from feeling hungry, which helps you consume fewer calories throughout the day.



Improved immune system

Eggs contain ingredients like protein, vitamin D, folate, and vitamin B that play an important role in boosting immunity while also preventing the spread of viruses and bacteria in the body. Also, eggs are rich in selenium, which not only boosts immunity but also reduces DNA damage and destroys cancer cells.

Improves vision

For those who cannot get omega-3 from fish, eggs are an excellent source of omega-3. Omega-3 is very useful for improving brain function and vision. Along with this, it also contains antioxidants that play an important role in protecting the eyes.

Best way to get choline

Choline is a nutrient that most people fail to get enough of, while eggs are a great source of choline.

Choline plays an important role in building cell membranes and signaling molecules in other organs of the body as well as in the brain. One egg contains 100 mg of choline.

Normal blood pressure level

Potassium found in egg white plays a very important role in keeping high blood pressure normal. Potassium is a nutrient that improves heart health as well as bone health.

Improves the health of blood vessels

Egg whites reduce high blood pressure, which in turn reduces the risk of coronary artery disease. This diet contains ingredients that do not narrow the blood vessels but keep them wide. Keeping these arteries wide does not affect the flow of blood and does not create a risk of blood clots.

Muscle weakness and headache

Eggs are rich in nutrients like vitamins A and B2, so their consumption reduces the risk of age-related diseases such as muscle weakness, cataracts, and migraines.

Bone strength

Eggs also contain significant amounts of vitamin D, which is considered important for strengthening bones. Therefore, by regularly consuming eggs, the body gets the required amount of vitamin D, which not only keeps the bones strong but also reduces the risks of bone diseases.

Some people use only egg whites while others like only the yolk. Whites and yolks have their own benefits, so let’s take a look at them.

Benefits of Boiled Egg Whites

The following benefits can be obtained from egg whites

Egg whites do not contain cholesterol, which does not increase the risk of heart disease.

It is low in calories which does not cause weight gain –

It is rich in protein which strengthens the muscles –

Many benefits can be obtained from egg white as well as its yolk.

 Boiled Egg yolk Benefits

The following benefits can be obtained from egg yolk

1- Egg yolk makes hair shiny

2- Beautifies the skin

3- Keeps us agile and energetic bone

Boiled Egg benefits for men

Due to their high protein content, eggs are a healthy choice to enhance sperm count. Additionally, eggs increase sperm motility and shield them from harmful free radicals. The nutrients in an egg promote the production of sperm that are stronger and healthier, enhancing fertility.


Pomegranate juice benefits

Pomegranate juice benefits

Pomegranate juice benefits

Pomegranate juice benefits high in antioxidants and anti-inflammatory compounds. Benefits Pomegranate juice may be beneficial to persons suffering from inflammatory disorders, diabetes, and other health problems. It may also improve digestion and cognition, as well as help prevent cancer.

Pomegranate juice benefits may provide health benefits such as being an antioxidant, which may help prevent cancer and other diseases, giving vitamin C, improving digestive health, and lowering insulin resistance.

It may aid in the prevention of cancer, immunological support, and fertility.

Some of the specific benefits of pomegranates include:

  1. Antioxidant effects

Pomegranate contains antioxidant polyphenols. Fruit antioxidants lower (reactive oxygen species) ROS, a kind of free radical, in the body. Metabolism generates ROS. Toxins like cigarette smoke raise ROS levels. ROS may cause oxidative stress, cell damage, and inflammation. Oxidative stress may cause metabolic disease, cancer, and other illnesses. Antioxidants eliminate ROS. Pomegranate juice antioxidants eliminate ROS and safeguard the body.


  1. Nutrient Boost

Pomegranate is a rich source of:

vitamin E (antioxidant), vitamin K (blood coagulation), and magnesium (blood pressure and glucose management).


  1. Cancer prevention

According to the NIH, pomegranate juice benefits may cure or prevent prostate cancer. Pomegranate polyphenols may suppress prostate cancer cell development. Pomegranate fruit extract reduced prostate-specific antigen and tumour development in mice. Pomegranate ingredients may prevent breast, lung, and skin cancer.


  1. Good source of fibre

According to the United States Department of Agriculture, pomegranate arils are high in fibre. Insoluble fibre aids in the health of our digestive tracts. It may help maintain stable blood sugar levels and keep us satisfied at mealtimes.


  1. Provides Vitamin C

Moon claims pomegranate arils provide vitamin C per half cup. That half cup contains 9 mg of vitamin C, 10% of the adult DV.

Humans need vitamin C since most animals can make it themselves. Vitamin C, an antioxidant, helps other antioxidants operate properly. Protein metabolism, collagen synthesis, and neurotransmitter generation need the vitamin. It boosts immunological function and absorbs non-heme iron from plant sources.



  1. Support urinary health

Antioxidant-rich pomegranate extract may prevent kidney stone development in test-tube and human studies. One trial gave 1,000 mg of pomegranate extract to 18–70-year-olds with recurring kidney stones for 90 days. This inhibited body stone formation. Pomegranate extract also regulates blood oxalates, calcium, and phosphates, which are kidney stone components, in animal experiments. Pomegranate antioxidants may minimise kidney stones.


  1. Improve Kidney Health

In the U.S., 11% of men and 6% of women have kidney stones. Untreated, they may produce blood in the urine, severe discomfort, and renal problems. Phyto phenols in pomegranates reduce kidney stones, according to research.


  1. Offer complex carbohydrates

Carbohydrates are a macronutrient category that humans need at every meal and snack, despite recent reminders in diet culture to the contrary. In reality, around half (or more, depending on your specific needs) of the diet must consist of carbohydrates. Incorporating pomegranate arils and juice into meals and snacks may help us satisfy our carbohydrate requirements.


Thus, Pomegranate juice benefits, are rich in antioxidant compounds that protect cells from harm caused by free radicals. The arils are also abundant in fibre, which acts as food for probiotics and aids in the prevention of some digestive disorders. You may get the health advantages of pomegranate by consuming its seeds, or arils.




What is the survival rate of pancreatic cancer?

Aslamo Alicum sir I am Dr. Ali Hasan Radiology Specialist from Bahawalnagar.
Sir, I have three questions.

What is the survival rate of pancreatic cancer?

We read that the entire pancreas is not removed.

So I want to know that

What is the percentage survival rate after medication and surgery?

My second question is should it be corrected with medication or is it better to go for a liver transplant in the beginning? Some experts say that a liver transplant may be the best solution if the liver is headed for failure in the beginning.
Can it be treated medically for some time?
My third question is
Many slim people have also been found to suffer from fatty liver and it is also the case that many obese people do not suffer from fatty liver.
My question is that it is definitely linked to Leopard’s profile.

But what percentage does it measure that the cholesterol is high?

Sir, I have a friend who recently had dengue which started his ALT to rise.
Liver-related symptoms will not be found in the patient.
Will he need a protective agent to increase his platelets or not?

Thank you very much doctor I will try to explain it briefly.
Liver cancer is considered among the most dangerous cancers Unfortunately, 80 to 85 percent of patients are diagnosed with this cancer when they have advanced to stage four.
So in this case the chance of survival can be up to 3 months without chemotherapy and 9 months with chemo and up to one and half years at most.
Patients with early-stage liver cancer may have their liver removed.
In summary, it is dangerous cancer and is curable if diagnosed at an early stage.
Early diagnosis occurs in 10 to 15 percent of patients and surgical resection is the only ray of hope

Early stage means the cancer is limited to the pancreas and can be surgically removed.


Your second question was related to Bud Carrey Syndrome which is very common in Pakistan
There are three different types of treatment for this type of patient.
Patients with bud carriers eventually require liver transplantation

Hi, How Can We Help You?